Simulations Plus: End-to-end clinical trial modeling with the Thales QSP software platform

This workshop provides an in-depth introduction to Thales, a cloud-based quantitative systems pharmacology (QSP) modeling platform with a focus on simulating virtual clinical trials. The 1-day session includes both lectures and hands-on exercises, aimed at familiarizing participants with the platform's core functionalities and its use in translational and clinical modeling contexts. Lectures will cover key features of the platform, specifically highlighting standardization of model representation, fitting, and validation. Emphasis will be placed on the platform's native support of virtual populations and ability to simultaneously optimize data spanning numerous therapeutic interventions, as well as the suite of integrated software tools that enable the design and execution of virtual clinical trials. Finally, the workshop will conclude with a preview of how Thales integrates AI, giving a glimpse into the future of QSP modeling. Practical sessions will allow participants to apply these concepts directly, using case-based examples relevant to current needs in model-informed drug development. Users will gain first-hand experience using the cloud-based platform in setting up simulations, using peripheral tools, and interpreting model outputs. The workshop is intended for modelers and scientists with experience working in QSP and interest in an end-to-end modeling platform for virtual trial simulation.