Translation of weight loss and prediction of liver pharmacodynamics in NASH across a range of mechanisms by quantitative systems pharmacology modeling

In this work, OBESITYsym was employed to predict weight loss via both nutritional intervention as well as via treatment with tirzepatide. These results were then carried to NAFLDsym to predict the resultant changes in steatosis and fibrosis. This hypothesis asserted that excess adiposity was the pathogenic driving factor for a constellation of metabolic disease (type 2 diabetes, hypertension, cardiovascular disease, etc.) and effective weight loss treatments would provide relief of downstream pathophyisologies as well, which has been in agreement with clinical observations.