Stephan Schaller, PhD: No financial relationships to disclose
Description: The latest OSP Suite V12 introduces a modularization approach that enhances the flexibility, scalability, and efficiency of QSP modeling and integrations with PBPK. This full-day hands-on workshop will equip participants with the skills to leverage modular workflows in MoBi to build, extend, and refine PBPK-QSP models like never before.
Led by ESQlabs scientists, attendees will start with a simple two-compartment model to grasp the fundamentals of modularization before diving into a real-world case study: modeling an ADC modality for tumor treatment.
Attendees will master the new modular approach in MoBi, learning how to build and manage complex models in a structured way. While automated model qualification will be touched upon as an outlook, the focus will be on hands-on modeling and modularization techniques that enhance collaboration, transparency, and reusability in PBPK-QSP modeling.
Learning Objectives:
Develop a PBPK model for the large molecule and small molecule payload.
Modularization 1: adding a Target-Mediated Drug Disposition reaction network as a reaction extension module.
Modularization 2: adding a tumor organ as a physiological extension module.
Modularization 3: Implement a pharmacodynamic effect extension module to simulate tumor growth inhibition.
Work with separate modules to demonstrate how modular workflows streamline model management, reuse, and extension.
