Full Schedule

7:00 AM - 9:00 AM MDT

Exhibits/ Posters/ Coffee Service

Location: Colorado Ballroom A & Foyer

7:00 AM - 5:00 PM MDT

ACoP Registration Desk - Hours

Location: Colorado Foyer

8:15 AM - 8:45 AM MDT

Meet the SIG's

Location: ISoP Lounge

9:00 AM - 9:45 AM MDT

Presidents Address

Location: Colorado B-D

Presenter: – PUMAS Inc

Presenter:

9:45 AM - 9:50 AM MDT

Keynote Speaker Introduction

Location: Colorado B-D

Speaker: – Genentech

9:45 AM - 10:45 AM MDT

Keynote - Drug Discovery and Development in the Age of AI Agents

Location: Colorado B-D

Keynote Speaker: – Stanford

10:45 AM - 11:00 AM MDT

Coffee Service

Location: Colorado Foyer

11:00 AM - 12:30 PM MDT

Differentiated MIDD strategies to accelerate clinical development in metabolic diseases are worth their weight

Location: Colorado B-D

Co-Chair: – Pfizer Inc

Co-Chair: – Madrigal Pharmaceuticals

Speaker: – Eli Lilly and Company

Speaker: – Novo Nordisk

Speaker: – Simulations Plus

Speaker: – Certara Predictive Technologies

Special Populations

11:00 AM - 11:22 AM MDT

Pharmacokinetics of incretin mimetics: a forward-looking perspective

Location: Colorado B-D

Speaker: – Eli Lilly and Company

11:22 AM - 11:45 AM MDT

MIDD for semaglutide – contributions from different modelling approaches throughout the value chain

Location: Colorado B-D

Speaker: – Novo Nordisk

11:45 AM - 12:07 PM MDT

Translation of weight loss and prediction of liver pharmacodynamics in NASH across a range of mechanisms by quantitative systems pharmacology modeling

Location: Colorado B-D

Speaker: – Simulations Plus

12:07 PM - 12:30 PM MDT

Considerations for physiologically based pharmacokinetic and pharmacodynamic (PBPK-PD) modeling to facilitate drug development in obese and related specific populations

Location: Colorado B-D

Speaker: – Certara Predictive Technologies

11:00 AM - 12:30 PM MDT

Harnessing Physics-Informed Machine Learning for Predictive Pharmacology and Oncology Drug Development

Location: Willow Lake 3

Co-Chair: – Biomedical Engineering, Brown University

Co-Chair: – University of Waterloo

Speaker: – Bristol Myers Squibb

Speaker: – Novartis

Stats/ AIML/ Big Data

11:00 AM - 11:22 AM MDT

State-Space Model for Predicting Antitumor Drug Efficacy

Location: Willow Lake 3

Speaker: – Biomedical Engineering, Brown University

11:22 AM - 11:45 AM MDT

Integrating Quantitative Systems Pharmacology with Machine Learning to Enhance Predictive Accuracy and Personalization in Cancer Immunotherapy

Location: Willow Lake 3

Speaker: – University of Waterloo

11:45 AM - 12:07 PM MDT

Exploring the Transformer Model in Longitudinal Pharmacokinetic/Pharmacodynamic Analysis

Location: Willow Lake 3

Speaker: – Bristol Myers Squibb

12:07 PM - 12:30 PM MDT

In silico first – by harnessing the strengths of AI/ML + PK/PD to drive the discovery of targeted protein degraders

Location: Willow Lake 3

Speaker: – Novartis

11:00 AM - 12:30 PM MDT

Applications and Challenges of MIDD in Nucleic Acid therapies

Location: Red Rock 8/9

Co-Chair: – Sarepta Therapeutics

Co-Chair: – Translational Consulting, L.L.C.

Speaker: – Ionis Pharmaceuticals

Speaker: – Intellia Therapeutics

Panelist: – Metrum Research Group

General Pharmacometrics

11:00 AM - 11:20 AM MDT

Application and Challenges of Pharmacometrics in siRNAs

Location: Red Rock 8/9

Speaker: – Translational Consulting, L.L.C.

11:20 AM - 11:40 AM MDT

Application and Challenges of Pharmacometrics in Antisense Oligonucleotides

Location: Red Rock 8/9

Speaker: – Ionis Pharmaceuticals

11:40 AM - 12:00 PM MDT

Clinical Pharmacology and Translational Considerations in the Development of CRISPR-Based Therapies

Location: Red Rock 8/9

Speaker: – Intellia Therapeutics

12:00 PM - 12:30 PM MDT

Panel - Applications and Challenges of MIDD in Nucleic Acid therapies

Location: Red Rock 8/9

Panelist: – Translational Consulting, L.L.C.

Panelist: – Ionis Pharmaceuticals

Panelist: – Intellia Therapeutics

Panelist: – Metrum Research Group

12:30 PM - 2:00 PM MDT

Exhibits/ Posters/ Lunch

Location: Colorado Ballroom A & Foyer

12:30 PM - 2:00 PM MDT

STEP (Students, Trainees, Early Professionals) Lunch

Location: Red Rock 6/7

2:00 PM - 3:30 PM MDT

Expanding Opportunities for Pharmacometrics in the Era of Digital Health

Location: Colorado B-D

Chair: – Critical Path Institute

Speaker: – Alberta Diabetes Institute, University of Alberta

Speaker: – Data, Analytics and Research, Roche Information Solutions

Speaker: – Genentech

Panelist: – critical path institute

Big Data/AI/Machine Learning

2:00 PM - 2:20 PM MDT

Continuous Progress: Harnessing Continuous Glucose Monitoring to Enhance Early-Stage Type 1 Diabetes Clinical Trials

Location: Colorado B-D

Speaker: – Alberta Diabetes Institute, University of Alberta

2:20 PM - 2:40 PM MDT

AI-Driven Insights: Leveraging Digital Health Technologies for Enhanced Clinical Drug Development

Location: Colorado B-D

Speaker: – Genentech

2:40 PM - 3:00 PM MDT

Digital Health: from Drug Development to Diagnostics

Location: Colorado B-D

Speaker: – Data, Analytics and Research, Roche Information Solutions

3:00 PM - 3:30 PM MDT

Panel - Expanding Opportunities for Pharmacometrics in the Era of Digital Health

Location: Colorado B-D

Panelist: – Alberta Diabetes Institute, University of Alberta

Panelist: – Genentech

Panelist: – Data, Analytics and Research, Roche Information Solutions

Panelist: – critical path institute

2:00 PM - 3:30 PM MDT

An immune booster: QSP modeling to advance the treatment for autoimmune diseases

Location: Willow Lake 3 - 5

Co-Chair: – Eli Lilly and Company

Co-Chair: – Bristol Myers Squibb

Speaker: – Gilead Sciences

Speaker: – Certara Applied BioSimulation, Sheffield, United Kingdom

Speaker: – Nanjing Medical University

Speaker: – AstraZeneca

QSP/ PBPK

2:00 PM - 2:20 PM MDT

Integrated systems pharmacology modeling of severe asthma and the IL-33/ST2 pathway

Location: Willow Lake 3 - 5

Speaker: – Gilead Sciences

2:20 PM - 2:40 PM MDT

Combining mechanistic modeling with machine learning as a strategy to predict inflammatory bowel disease clinical scores

Location: Willow Lake 3 - 5

Speaker: – Certara Applied BioSimulation, Sheffield, United Kingdom

2:40 PM - 3:00 PM MDT

Implementing QSP modeling in the clinical translation of mesenchymal stem cells in autoimmune diseases: a case study in lupus nephritis

Location: Willow Lake 3 - 5

Speaker: – Nanjing Medical University

3:00 PM - 3:20 PM MDT

Hybrid mechanistic-ML model of Crohn’s disease to predict temporal progression of mucosal damage in patients

Location: Willow Lake 3 - 5

Speaker: – AstraZeneca

3:20 PM - 3:30 PM MDT

Panel - An immune booster: QSP modeling to advance the treatment for autoimmune diseases

Location: Willow Lake 3 - 5

Panelist: – Gilead Sciences

Panelist: – Certara Applied BioSimulation, Sheffield, United Kingdom

Panelist: – Nanjing Medical University

Panelist: – AstraZeneca

2:00 PM - 3:30 PM MDT

High-impact Applications of Model-based Meta-analyses (MBMA) in Drug Development

Location: Red Rock 8/9

Co-Chair: – Certara

Co-Chair: – GSK

Speaker: – AstraZeneca

Speaker: – Uppsala University

General Pharmacometrics

2:00 PM - 2:20 PM MDT

Tackling pain: a platform MBMA approach Session title: High-impact Applications of Model-based Meta-analyses (MBMA) in Drug Development

Location: Red Rock 8/9

Speaker: – GSK

2:20 PM - 2:40 PM MDT

Model-Based Meta-Analysis Leveraging Publicly Available Data to Support Drug Development in Weight-management

Location: Red Rock 8/9

Speaker: – AstraZeneca

2:40 PM - 3:00 PM MDT

Combining aggregate and individual level data – opportunities and considerations Session title: High-impact Applications of Model-based Meta-analyses (MBMA) in Drug Development

Location: Red Rock 8/9

Speaker: – Uppsala University

3:00 PM - 3:30 PM MDT

Panel - High-impact Applications of Model-based Meta-analyses (MBMA) in Drug Development

Location: Red Rock 8/9

Panelist: – Certara

Panelist: – GSK

Panelist: – AstraZeneca

Panelist: – Uppsala University

4:00 PM - 5:00 PM MDT

Exhibits/ Posters/ Coffee Break

Location: Colorado Ballroom A & Foyer

5:00 PM - 6:30 PM MDT

STEP Communication Challenge

Location: Red Rock 8/9

Co-Chair: – University of Minnesota

Co-Chair: – SJTPharm LLC

7:00 PM - 11:00 PM MDT

Social Dinner Event - A Night of Lights

Location: Aurora A

7:00 PM - 11:00 PM MDT

The Chill Out Lounge

Location: Crest 3/4